Probing Biomolecules by Laser-Induced Acoustic Desorption: Electrons at Near Zero Electron Volts Trigger Sugar-Phosphate Cleavage

Making the cut: Electrons at energies close to 0 eV have been shown to be resonantly captured by gas‐phase D‐ribose‐5‐phosphate (a model compound for the DNA and RNA backbone) with subsequent cleavage of the sugar–phosphate linkage (see scheme). This supports the idea that breakage of DNA strands by...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (44), p.8518-8520
Main Authors: Bald, Ilko, Dąbkowska, Iwona, Illenberger, Eugen
Format: Article
Language:English
Subjects:
Acoustics
analytical methods
DNA - chemistry
DNA - radiation effects
DNA Breaks, Single-Stranded
DNA Cleavage
Electrons
gas‐phase reactions
Lasers
mass spectrometry
Methods
Sugar Phosphates - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Making the cut: Electrons at energies close to 0 eV have been shown to be resonantly captured by gas‐phase D‐ribose‐5‐phosphate (a model compound for the DNA and RNA backbone) with subsequent cleavage of the sugar–phosphate linkage (see scheme). This supports the idea that breakage of DNA strands by electrons at very low energies are triggered by dissociative electron attachment directly to the DNA/RNA backbone.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200803382