Glycopeptide insensitive Staphylococcus aureus subdural empyema treated with linezolid and rifampicin

Summary A 4-year-old boy had surgical debulking of a cerebral astrocytoma followed by chemotherapy. He developed a subdural empyema with a teicoplanin and methicillin resistant Staphylococcus aureus . He was successfully treated with surgical drainage and 6 weeks of antibiotic therapy which included...

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Bibliographic Details
Published in:The Journal of infection 2008-11, Vol.57 (5), p.410-413
Main Authors: Gallagher, R.M, Pizer, B, Ellison, J.A, Riordan, F.A.I
Format: Article
Language:English
Subjects:
Acetamides - therapeutic use
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Biological and medical sciences
Child, Preschool
Drainage
Drug Resistance, Multiple, Bacterial
Drug Therapy, Combination
Empyema, Subdural - microbiology
Empyema, Subdural - therapy
General aspects
Glycopeptide insensitive Staphylococcus aureus
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Linezolid
Male
Medical sciences
Methicillin resistant Staphylococcus aureus
Microbial Sensitivity Tests
Oxazolidinones - therapeutic use
Pharmacology. Drug treatments
Rifampin - therapeutic use
Staphylococcal Infections - drug therapy
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Subdural empyema
Teicoplanin - therapeutic use
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Summary:Summary A 4-year-old boy had surgical debulking of a cerebral astrocytoma followed by chemotherapy. He developed a subdural empyema with a teicoplanin and methicillin resistant Staphylococcus aureus . He was successfully treated with surgical drainage and 6 weeks of antibiotic therapy which included linezolid, rifampicin and metronidazole. Linezolid may be successful in treating other CNS infections caused by antibiotic resistant gram-positive organisms.
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2008.06.023