Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils

By using neonatal gerbils, we assessed the effect of ribavirin on the proliferation of Borna disease virus (BDV) in the brain. The intracranial inoculation of ribavirin reduced viral propagation in the acutely infected brain, resulting in protection from fatal neurological disorders. We found that t...

Full description

Saved in:
Bibliographic Details
Published in:Antiviral research 2008-12, Vol.80 (3), p.380-384
Main Authors: Lee, Byeong-Jae, Matsunaga, Hidenori, Ikuta, Kazuyoshi, Tomonaga, Keizo
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - virology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - pharmacology
Biological and medical sciences
Borna Disease - drug therapy
Borna Disease - virology
Borna disease virus
Borna disease virus - drug effects
Borna disease virus - physiology
Brain - virology
Female
Gerbillinae
Infectious diseases
Male
Medical sciences
Mongolian gerbils
Nervous System Diseases - drug therapy
Nervous System Diseases - veterinary
Nervous System Diseases - virology
Neurological disorder
Pharmacology. Drug treatments
Ribavirin
Ribavirin - pharmacology
Rodent Diseases - drug therapy
Rodent Diseases - virology
Viral diseases
Virus Replication - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:By using neonatal gerbils, we assessed the effect of ribavirin on the proliferation of Borna disease virus (BDV) in the brain. The intracranial inoculation of ribavirin reduced viral propagation in the acutely infected brain, resulting in protection from fatal neurological disorders. We found that the treatment with ribavirin markedly reduces the numbers of OX-42-positive microglial cells, but does not activate expression of Th1 cytokines, in BDV-infected gerbil brains. Our results suggested that ribavirin directly inhibits BDV replication and might be a potential tool for the treatment of BDV infection.
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2008.08.001