Opposite modulation of cortical N-methyl- d-aspartate receptor-mediated responses by low and high concentrations of dopamine

To examine whether dopamine modulates cortical N-methyl- d-aspartate receptor-mediated glutamate transmission, whole-cell recordings were made from identified pyramidal cells located in layers V and VI of the medial prefrontal cortex of the rat using a slice preparation. In the presence of tetrodoto...

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Bibliographic Details
Published in:Neuroscience 1999-01, Vol.91 (2), p.527-535
Main Authors: Zheng, P., Zhang, X.-X., Bunney, B.S., Shi, W.-X.
Format: Article
Language:English
Subjects:
1-Methyl-3-isobutylxanthine - pharmacology
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology
Animals
antipsychotic drug
Benzazepines - pharmacology
Biological and medical sciences
cAMP
Central nervous system
Dizocilpine Maleate - pharmacology
dopamine
Dopamine - pharmacology
Dopamine Agonists - pharmacology
Dopamine Antagonists - pharmacology
Dose-Response Relationship, Drug
Electrophysiology
Excitatory Amino Acid Antagonists - pharmacology
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Male
Membrane Potentials - drug effects
NMDA
prefrontal cortex
Prefrontal Cortex - drug effects
Prefrontal Cortex - physiology
Pyramidal Cells - drug effects
Pyramidal Cells - physiology
Quinoxalines - pharmacology
Quinpirole - pharmacology
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - drug effects
Receptors, N-Methyl-D-Aspartate - physiology
schizophrenia
Vertebrates: nervous system and sense organs
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Summary:To examine whether dopamine modulates cortical N-methyl- d-aspartate receptor-mediated glutamate transmission, whole-cell recordings were made from identified pyramidal cells located in layers V and VI of the medial prefrontal cortex of the rat using a slice preparation. In the presence of tetrodotoxin and the absence of Mg 2+, a brief local application of N-methyl- d-aspartate evoked an inward current which was blocked by the N-methyl- d-aspartate antagonist dizocilpine maleate but not affected by the non- N-methyl- d-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline, suggesting that the observed current is mediated by N-methyl- d-aspartate receptors located on recorded cells. Bath application of dopamine produced opposite effects on the N-methyl- d-aspartate current depending on the concentrations of dopamine applied. At low concentrations (
ISSN:0306-4522
1873-7544
DOI:10.1016/S0306-4522(98)00604-6