Projections From the Anterior Interposed Nucleus to the Red Nucleus Diminish With Age in the Mouse

To analyse the effect of ageing on the projection of the anterior interposed nucleus to the red nucleus, we injected the retrograde tracer fluorogold in the red nucleus of 3-, 6- and 12-month-old mice. The number of labelled neurones in the anterior interposed nucleus fell by 9% between 3 and 6 mont...

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Bibliographic Details
Published in:Anatomia, histologia, embryologia histologia, embryologia, 2008-12, Vol.37 (6), p.438-441
Main Authors: Olyntho-Tokunaga, H.H.V, Pinto, M.L, Souccar, C, Schoorlemmer, G.H.M, Lapa, R.C.R.S
Format: Article
Language:English
Subjects:
Afferent Pathways - anatomy & histology
Aging - physiology
Animals
Brain Mapping
Cerebellar Nuclei - cytology
Cerebellar Nuclei - metabolism
Male
Mice
Mice, Inbred C57BL
Nerve Degeneration - metabolism
Neurons - pathology
Neurons - physiology
Red Nucleus - anatomy & histology
Red Nucleus - cytology
Red Nucleus - metabolism
Staining and Labeling
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Summary:To analyse the effect of ageing on the projection of the anterior interposed nucleus to the red nucleus, we injected the retrograde tracer fluorogold in the red nucleus of 3-, 6- and 12-month-old mice. The number of labelled neurones in the anterior interposed nucleus fell by 9% between 3 and 6 months and by another 9% between 6 and 12 months (all P < 0.001). This suggests that loss of neurones from the cerebellar nuclei starts well before old age.
ISSN:0340-2096
1439-0264
DOI:10.1111/j.1439-0264.2008.00877.x