Expression of mucin 1 (MUC1) in esophageal squamous‐cell carcinoma: Its relationship with prognosis

Using 2 anti‐mucin 1 (MUC1) monoclonal antibodies (MAbs), DF3 and BCP8, we examined MUC1 expression immunohistochemically in 192 esophageal squamous‐cell carcinomas (SCCs). In normal squamous epithelium of the esophagus, DF3 was not expressed, but BCP8 was expressed on the cell membrane, mainly in t...

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Bibliographic Details
Published in:International journal of cancer 1999-06, Vol.84 (3), p.251-257
Main Authors: Sagara, Mitsuhisa, Yonezawa, Suguru, Nagata, Koji, Tezuka, Yoshihisa, Natsugoe, Shoji, Xing, Pei‐Xiang, McKenzie, Ian F.C., Aikou, Takashi, Sato, Eiichi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Esophageal Neoplasms - chemistry
Esophageal Neoplasms - mortality
Esophageal Neoplasms - pathology
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Medical sciences
Mucin-1 - analysis
Mucin-1 - immunology
Prognosis
Survival Rate
Tumors
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Summary:Using 2 anti‐mucin 1 (MUC1) monoclonal antibodies (MAbs), DF3 and BCP8, we examined MUC1 expression immunohistochemically in 192 esophageal squamous‐cell carcinomas (SCCs). In normal squamous epithelium of the esophagus, DF3 was not expressed, but BCP8 was expressed on the cell membrane, mainly in the surface layer. In esophageal SCCs, DF3 and BCP8 were expressed mainly on the cell membrane of SCC cells, but also in the cytoplasm in several cases. To analyze the correlation of MUC1 expression and the prognosis of the patients, the 192 cases were divided into 2 groups: high‐expression group (HEG, >50% of the neoplastic cells stained) and low‐expression group (LEG,
ISSN:0020-7136
1097-0215
DOI:10.1002/(SICI)1097-0215(19990621)84:3<251::AID-IJC9>3.0.CO;2-7