Gastrointestinal Symptoms in Children with an Autism Spectrum Disorder and Language Regression

Few studies have compared gastrointestinal problems in children with an autism spectrum disorder with and without a history of language regression. A cross-sectional study was conducted with structured interviews in 100 children with autism spectrum disorder, using a gastrointestinal questionnaire a...

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Bibliographic Details
Published in:Pediatric neurology 2008-12, Vol.39 (6), p.392-398
Main Authors: Valicenti-McDermott, Maria D., MD, MS, McVicar, Kathryn, MD, Cohen, Herbert J., MD, Wershil, Barry K., MD, Shinnar, Shlomo, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Autistic Disorder - complications
Autoimmune Diseases - genetics
Biological and medical sciences
Child
Child clinical studies
Child, Preschool
Developmental disorders
Family Health
Female
Gastrointestinal Diseases - etiology
Humans
Infant
Infantile autism
Language Development Disorders - complications
Male
Medical sciences
Multivariate Analysis
Neurology
Pediatrics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Retrospective Studies
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Summary:Few studies have compared gastrointestinal problems in children with an autism spectrum disorder with and without a history of language regression. A cross-sectional study was conducted with structured interviews in 100 children with autism spectrum disorder, using a gastrointestinal questionnaire and a familial autoimmune questionnaire. By parental report, children with language regression more frequently exhibited an abnormal stool pattern (40% vs 12%, P = 0.006) and had an increased family history of celiac disease or inflammatory bowel disease (24% vs 0%, P = 0.001) and of rheumatoid arthritis (30% vs 11%, P = 0.03). Among 35 children with a family history of autoimmune disease, an abnormal stool pattern was reported more frequently in those with language regression (78% vs 15%, P = 0.001) than in those without. An association was observed between children with language regression, a family history of autoimmune disease, and gastrointestinal symptoms. Additional studies are needed to examine a possible shared autoimmune process.
ISSN:0887-8994
1873-5150
DOI:10.1016/j.pediatrneurol.2008.07.019