Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers

Objective. Patients with gastroesophageal reflux disease (GERD) are advised to avoid alcoholic beverages since alcohol consumption induces gastroesophageal reflux in healthy volunteers and increases it in patients with GERD. Proton-pump inhibitors (PPIs) are frequently administered for reflux sympto...

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Published in:Scandinavian journal of gastroenterology 2008, Vol.43 (12), p.1425-1431
Main Authors: Franke, Andreas, Hepp, Caroline, Harder, Hermann, Beglinger, Christoph, Singer, Manfred V.
Format: Article
Language:English
Subjects:
Adult
Beer - adverse effects
Biological and medical sciences
Digestive system
Double-Blind Method
Esomeprazole - pharmacology
Esomeprazole - therapeutic use
Esophageal disorders
Esophageal pH Monitoring
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - etiology
Humans
Male
Medical sciences
motility
nutrition
Other diseases. Semiology
Pharmacology. Drug treatments
Proton Pump Inhibitors - pharmacology
Proton Pump Inhibitors - therapeutic use
Treatment Outcome
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cited_by cdi_FETCH-LOGICAL-c434t-e56c1773a29f10ffc7b8c5edfcbee1ee8cabf3c9b6ff90478db494fad0aefc863
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container_end_page 1431
container_issue 12
container_start_page 1425
container_title Scandinavian journal of gastroenterology
container_volume 43
creator Franke, Andreas
Hepp, Caroline
Harder, Hermann
Beglinger, Christoph
Singer, Manfred V.
description Objective. Patients with gastroesophageal reflux disease (GERD) are advised to avoid alcoholic beverages since alcohol consumption induces gastroesophageal reflux in healthy volunteers and increases it in patients with GERD. Proton-pump inhibitors (PPIs) are frequently administered for reflux symptoms but their effect on gastroesophageal reflux after alcohol consumption has not yet been fully studied. The aim of the present study was therefore to investigate the effect of esomeprazole, an S-enantiomer of omeprazole, on gastroesophageal reflux after beer consumption. Material and methods. In this placebo-controlled, double-blind, crossover study, 16 healthy male volunteers received 20 mg esomeprazole daily for one week. On day 7, in an acute experiment, the subjects then consumed 500 ml beer within 5 min. Subsequently, gastroesophageal reflux was monitored by pH-metry over a period of 3 h. In addition, gastric emptying was measured by ultrasonography and blood concentrations of ethanol, cholecystokinin and gastrin were determined. Results. Gastroesophageal reflux was significantly (p=0.001) reduced by 93% after treatment with esomeprazole (0.2%, median percentage of time pH
doi_str_mv 10.1080/00365520802105110
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Patients with gastroesophageal reflux disease (GERD) are advised to avoid alcoholic beverages since alcohol consumption induces gastroesophageal reflux in healthy volunteers and increases it in patients with GERD. Proton-pump inhibitors (PPIs) are frequently administered for reflux symptoms but their effect on gastroesophageal reflux after alcohol consumption has not yet been fully studied. The aim of the present study was therefore to investigate the effect of esomeprazole, an S-enantiomer of omeprazole, on gastroesophageal reflux after beer consumption. Material and methods. In this placebo-controlled, double-blind, crossover study, 16 healthy male volunteers received 20 mg esomeprazole daily for one week. On day 7, in an acute experiment, the subjects then consumed 500 ml beer within 5 min. Subsequently, gastroesophageal reflux was monitored by pH-metry over a period of 3 h. In addition, gastric emptying was measured by ultrasonography and blood concentrations of ethanol, cholecystokinin and gastrin were determined. Results. Gastroesophageal reflux was significantly (p=0.001) reduced by 93% after treatment with esomeprazole (0.2%, median percentage of time pH&lt;4) as compared to placebo (2.6%), but gastric emptying, blood ethanol and cholecystokinin concentrations were not significantly different after esomeprazole treatment. Plasma gastrin levels were significantly (p=0.0003) higher after esomeprazole (98.6±19.7 pg/ml) than after placebo (22.7±3.8 pg/ml) before beer consumption. However, there was no difference in the increase in plasma gastrin after beer consumption between the esomeprazole treatment and placebo. Conclusions. Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers. Gastric emptying of beer is not prolonged after treatment with esomeprazole, although compared with placebo, this PPI induced significantly higher plasma gastrin concentrations. Moderate alcohol consumption does not worsen gastroesophageal reflux when a PPI is administered.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365520802105110</identifier><identifier>PMID: 18924018</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Adult ; Beer - adverse effects ; Biological and medical sciences ; Digestive system ; Double-Blind Method ; Esomeprazole - pharmacology ; Esomeprazole - therapeutic use ; Esophageal disorders ; Esophageal pH Monitoring ; Esophagus ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - drug therapy ; Gastroesophageal Reflux - etiology ; Humans ; Male ; Medical sciences ; motility ; nutrition ; Other diseases. Semiology ; Pharmacology. Drug treatments ; Proton Pump Inhibitors - pharmacology ; Proton Pump Inhibitors - therapeutic use ; Treatment Outcome</subject><ispartof>Scandinavian journal of gastroenterology, 2008, Vol.43 (12), p.1425-1431</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-e56c1773a29f10ffc7b8c5edfcbee1ee8cabf3c9b6ff90478db494fad0aefc863</citedby><cites>FETCH-LOGICAL-c434t-e56c1773a29f10ffc7b8c5edfcbee1ee8cabf3c9b6ff90478db494fad0aefc863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20938889$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18924018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franke, Andreas</creatorcontrib><creatorcontrib>Hepp, Caroline</creatorcontrib><creatorcontrib>Harder, Hermann</creatorcontrib><creatorcontrib>Beglinger, Christoph</creatorcontrib><creatorcontrib>Singer, Manfred V.</creatorcontrib><title>Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Objective. Patients with gastroesophageal reflux disease (GERD) are advised to avoid alcoholic beverages since alcohol consumption induces gastroesophageal reflux in healthy volunteers and increases it in patients with GERD. Proton-pump inhibitors (PPIs) are frequently administered for reflux symptoms but their effect on gastroesophageal reflux after alcohol consumption has not yet been fully studied. The aim of the present study was therefore to investigate the effect of esomeprazole, an S-enantiomer of omeprazole, on gastroesophageal reflux after beer consumption. Material and methods. In this placebo-controlled, double-blind, crossover study, 16 healthy male volunteers received 20 mg esomeprazole daily for one week. On day 7, in an acute experiment, the subjects then consumed 500 ml beer within 5 min. Subsequently, gastroesophageal reflux was monitored by pH-metry over a period of 3 h. In addition, gastric emptying was measured by ultrasonography and blood concentrations of ethanol, cholecystokinin and gastrin were determined. Results. Gastroesophageal reflux was significantly (p=0.001) reduced by 93% after treatment with esomeprazole (0.2%, median percentage of time pH&lt;4) as compared to placebo (2.6%), but gastric emptying, blood ethanol and cholecystokinin concentrations were not significantly different after esomeprazole treatment. Plasma gastrin levels were significantly (p=0.0003) higher after esomeprazole (98.6±19.7 pg/ml) than after placebo (22.7±3.8 pg/ml) before beer consumption. However, there was no difference in the increase in plasma gastrin after beer consumption between the esomeprazole treatment and placebo. Conclusions. Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers. Gastric emptying of beer is not prolonged after treatment with esomeprazole, although compared with placebo, this PPI induced significantly higher plasma gastrin concentrations. Moderate alcohol consumption does not worsen gastroesophageal reflux when a PPI is administered.</description><subject>Adult</subject><subject>Beer - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Esomeprazole - pharmacology</subject><subject>Esomeprazole - therapeutic use</subject><subject>Esophageal disorders</subject><subject>Esophageal pH Monitoring</subject><subject>Esophagus</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>Gastroesophageal Reflux - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>motility</subject><subject>nutrition</subject><subject>Other diseases. Semiology</subject><subject>Pharmacology. 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Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>Gastroesophageal Reflux - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>motility</topic><topic>nutrition</topic><topic>Other diseases. Semiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proton Pump Inhibitors - pharmacology</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franke, Andreas</creatorcontrib><creatorcontrib>Hepp, Caroline</creatorcontrib><creatorcontrib>Harder, Hermann</creatorcontrib><creatorcontrib>Beglinger, Christoph</creatorcontrib><creatorcontrib>Singer, Manfred V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franke, Andreas</au><au>Hepp, Caroline</au><au>Harder, Hermann</au><au>Beglinger, Christoph</au><au>Singer, Manfred V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2008</date><risdate>2008</risdate><volume>43</volume><issue>12</issue><spage>1425</spage><epage>1431</epage><pages>1425-1431</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Objective. Patients with gastroesophageal reflux disease (GERD) are advised to avoid alcoholic beverages since alcohol consumption induces gastroesophageal reflux in healthy volunteers and increases it in patients with GERD. Proton-pump inhibitors (PPIs) are frequently administered for reflux symptoms but their effect on gastroesophageal reflux after alcohol consumption has not yet been fully studied. The aim of the present study was therefore to investigate the effect of esomeprazole, an S-enantiomer of omeprazole, on gastroesophageal reflux after beer consumption. Material and methods. In this placebo-controlled, double-blind, crossover study, 16 healthy male volunteers received 20 mg esomeprazole daily for one week. On day 7, in an acute experiment, the subjects then consumed 500 ml beer within 5 min. Subsequently, gastroesophageal reflux was monitored by pH-metry over a period of 3 h. In addition, gastric emptying was measured by ultrasonography and blood concentrations of ethanol, cholecystokinin and gastrin were determined. Results. Gastroesophageal reflux was significantly (p=0.001) reduced by 93% after treatment with esomeprazole (0.2%, median percentage of time pH&lt;4) as compared to placebo (2.6%), but gastric emptying, blood ethanol and cholecystokinin concentrations were not significantly different after esomeprazole treatment. Plasma gastrin levels were significantly (p=0.0003) higher after esomeprazole (98.6±19.7 pg/ml) than after placebo (22.7±3.8 pg/ml) before beer consumption. However, there was no difference in the increase in plasma gastrin after beer consumption between the esomeprazole treatment and placebo. Conclusions. Esomeprazole significantly reduces gastroesophageal reflux after beer consumption in healthy volunteers. Gastric emptying of beer is not prolonged after treatment with esomeprazole, although compared with placebo, this PPI induced significantly higher plasma gastrin concentrations. Moderate alcohol consumption does not worsen gastroesophageal reflux when a PPI is administered.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>18924018</pmid><doi>10.1080/00365520802105110</doi><tpages>7</tpages></addata></record>
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subjects Adult
Beer - adverse effects
Biological and medical sciences
Digestive system
Double-Blind Method
Esomeprazole - pharmacology
Esomeprazole - therapeutic use
Esophageal disorders
Esophageal pH Monitoring
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - etiology
Humans
Male
Medical sciences
motility
nutrition
Other diseases. Semiology
Pharmacology. Drug treatments
Proton Pump Inhibitors - pharmacology
Proton Pump Inhibitors - therapeutic use
Treatment Outcome
title Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers
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