Positive Correlation between Cyclooxygenase 2 and the Expression of ABC Transporters in Non-small Cell Lung Cancer

Background: The primary method of treatment of non-small cell lung cancer (NSCLC) in stage IIIB and IV is chemotherapy. Previous data suggested a correlation between cyclooxygenase-2 (COX-2) expression and the multidrug-resistant phenotype of cancer cells. Materials and Methods: In this prospective...

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Published in:Anticancer research 2008-09, Vol.28 (5B), p.2967-2974
Main Authors: SUROWIAK, Pawel, PAWEŁCZYK, Konrad, LAGE, Hermann, MACIEJCZYK, Adam, PUDEŁKO, Marek, KOŁODZIEJ, Jerzy, ZABEL, Maciej, MURAWA, Dawid, DRAG, Marcin, GANSUKH, Tserenchunt, DIETEL, Manfred
Format: Article
Language:English
Subjects:
Aged
ATP-Binding Cassette Transporters - biosynthesis
Biological and medical sciences
Carcinoma, Non-Small-Cell Lung - enzymology
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Cyclooxygenase 2 - biosynthesis
Female
Humans
Lung Neoplasms - enzymology
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
Medical sciences
Middle Aged
Multivariate Analysis
Neoplasm Staging
Pneumology
Prospective Studies
Survival Rate
Tumors
Tumors of the respiratory system and mediastinum
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Summary:Background: The primary method of treatment of non-small cell lung cancer (NSCLC) in stage IIIB and IV is chemotherapy. Previous data suggested a correlation between cyclooxygenase-2 (COX-2) expression and the multidrug-resistant phenotype of cancer cells. Materials and Methods: In this prospective study, 32 patients with NSCLC in stage IIIB and IV from 1,078 patients were included. The expression of COX-2 as well as the expression of the ABC transporters MDR1/P-glycoprotein (MDR1/P-gp), BCRP and MRP1 were detected immunohistochemically. Results: Univariate and multivariate analyses demonstrated no prognostic or predictive significance of these proteins. It was merely demonstrated that complete or partial response are favourable factors for prediction of longer progression-free survival time. However, a strong positive correlation between the expression of COX-2, MDR1/P-gp and BCRP was found in NSCLC. Conclusion: These data suggest no clinical impact for the expression of MDR1/P-gp, MRP1, BCRP or COX-2 in NSCLC, but a putative coregulation of COX-2 and MDR1/P-gp and BCRP in NSCLC.
ISSN:0250-7005
1791-7530