beta-2 Adrenergic Receptor Variants Affect Resting Blood Pressure and Agonist-Induced Vasodilation in Young Adult Caucasians

Recent evidence suggests that the prodownregulatory Gly16 allele of the beta-2 adrenergic receptor (beta-2 AR) is associated with essential hypertension in African Caribbeans. To further investigate the effect of the glycine (Gly)16 and arginine (Arg)16 beta-2 AR variants on hemodynamics, we investi...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-06, Vol.33 (6), p.1425-1430
Main Authors: Gratze, Gerfried, Fortin, Jurgen, Labugger, Ralf, Binder, Alexander, Kotanko, Peter, Timmermann, Bernd, Luft, Friedrich C, Hoehe, Margret R, Skrabal, Falko
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - administration & dosage
Adrenergic beta-Agonists - pharmacology
Adult
Albuterol - administration & dosage
Albuterol - pharmacology
Alleles
Arginine
Arterial hypertension. Arterial hypotension
Austria
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - drug effects
Body Mass Index
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
European Continental Ancestry Group - genetics
Genetic Variation
Genotype
Glycine
Hemodynamics - drug effects
Hemodynamics - physiology
Heterozygote
Humans
Infusions, Intravenous
Male
Medical sciences
Polymorphism, Genetic
Receptors, Adrenergic, beta-2 - genetics
Stroke Volume - drug effects
Supine Position
Vasodilation - drug effects
Vasodilation - genetics
Vasodilation - physiology
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Summary:Recent evidence suggests that the prodownregulatory Gly16 allele of the beta-2 adrenergic receptor (beta-2 AR) is associated with essential hypertension in African Caribbeans. To further investigate the effect of the glycine (Gly)16 and arginine (Arg)16 beta-2 AR variants on hemodynamics, we investigated the agonist-mediated in vivo vasodilation in normotensive Austrian Caucasians and analyzed the results with respect to the Gly16/Arg16 polymorphism. Fifty-seven normotensive men, 20 to 32 years of age with body mass index of 18.7 to 29.9 kg/m, were genotyped for the Arg16/Gly16 beta-2 AR alleles. All 15 Gly16/Gly16 subjects, all 12 Arg16/Arg/16 subjects, and 27 of 30 heterozygous subjects underwent hemodynamic measurements while supine after an overnight fast. The observers were unaware of the subjects' genotypes. The subjects received a graded infusion of the selective beta-2 AR agonist salbutamol (0.07, 0.14, and 0.21 [micro sign]g/kg per minute, respectively), each dose over 8 minutes. Stroke volume and blood pressure were determined continuously by means of impedance cardiography and oscillometry, respectively. The last 4 minutes of each infusion were evaluated statistically. Basal mean blood pressure was higher in the Gly16/Gly16 subjects compared with Arg16/Arg16 subjects (mean +/- SD81.6 +/- 6.14 versus 75.2 +/- 4.93 mm Hg, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.33.6.1425