Transfer RNA modification: influence on translational frameshifting and metabolism

Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471–482]. Evidence that the presence of various modified nucleosides in t...

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Bibliographic Details
Published in:FEBS Letters 1999-06, Vol.452 (1), p.47-51
Main Authors: Björk, Glenn R, Durand, Jérôme M.B, Hagervall, Tord G, Leipuvien≐, Ramun≐, Lundgren, Hans K, Nilsson, Kristina, Chen, Peng, Qian, Qiang, Urbonavičius, Jaunius
Format: Article
Language:English
Subjects:
Central metabolism
Frameshifting
Frameshifting, Ribosomal - genetics
Frameshifting, Ribosomal - physiology
Modified nucleoside
RNA, Bacterial - genetics
RNA, Bacterial - metabolism
RNA, Transfer - genetics
RNA, Transfer - metabolism
tRNA
Virulence
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Summary:Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471–482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00528-1