Risperidone-induced increase of plasma norepinephrine is not correlated with symptom improvement in chronic schizophrenia

Background: Previous studies have shown an increase in plasma levels of norepinephrine (NE) after clozapine treatment of schizophrenia. This effect has been suggested to relate to improvement in symptoms. Methods: To test whether other novel antipsychotic drugs have such an effect, the present exper...

Full description

Saved in:
Bibliographic Details
Published in:Biological psychiatry (1969) 1999-06, Vol.45 (12), p.1653-1656
Main Authors: See, Ronald E, Fido, Abdullahi A, Maurice, Majed, Ibrahim, Mustafa M, Salama, Gamal M.S
Format: Article
Language:English
Subjects:
Adult
antipsychotic
Antipsychotic Agents - pharmacology
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Chronic Disease
Double-Blind Method
Female
haloperidol
Haloperidol - pharmacology
Haloperidol - therapeutic use
Humans
Male
Medical sciences
Neuropharmacology
norepinephrine
Norepinephrine - blood
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Risperidone
Risperidone - pharmacology
Risperidone - therapeutic use
schizophrenia
Schizophrenia - drug therapy
Schizophrenic Psychology
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Previous studies have shown an increase in plasma levels of norepinephrine (NE) after clozapine treatment of schizophrenia. This effect has been suggested to relate to improvement in symptoms. Methods: To test whether other novel antipsychotic drugs have such an effect, the present experiment examined schizophrenic symptoms and plasma levels of NE before and after 5 weeks of treatment with risperidone or haloperidol. Results: Risperidone, but not haloperidol, significantly increased plasma NE; however, there was no correlation of this effect with clinical improvement on any symptom scale. Conclusions: This finding suggests that risperidone shares similar properties with clozapine in enhancing peripheral NE, but that these changes in plasma NE may not be a consistent indicator of atypical antipsychotic drug efficacy. Biol Psychiatry 1999;45:1653–1656 © 1999 Society of Biological Psychiatry
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(98)00199-1