Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis: Aging and Arterial Compliance

The objective of this study was to evaluate age-related changes in pulsatile arterial function. Aging alters arterial pulsatile function and produces consistent changes in the pressure pulse contour. A reduced systemic arterial compliance that can be derived from analysis of the pulse contour is reg...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-06, Vol.33 (6), p.1392-1398
Main Authors: McVeigh, Gary E, Bratteli, Christopher W, Morgan, Dennis J, Alinder, Cheryl M, Glasser, Stephen P, Finkelstein, Stanley M, Cohn, Jay N
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Aging - physiology
Arteries - growth & development
Arteries - physiology
Biological and medical sciences
Blood Pressure - physiology
Blood vessels and receptors
Calibration
Diastole
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Middle Aged
Muscle, Smooth, Vascular - physiology
Pulse
Radial Artery - physiology
Regression Analysis
Sex Factors
Systole
Tonometry, Ocular
Vertebrates: cardiovascular system
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Summary:The objective of this study was to evaluate age-related changes in pulsatile arterial function. Aging alters arterial pulsatile function and produces consistent changes in the pressure pulse contour. A reduced systemic arterial compliance that can be derived from analysis of the pulse contour is regarded as the best clinical index of impaired pulsatile arterial function and may mark the presence of early vascular damage. We analyzed intra-arterial brachial artery waveforms in 115 healthy normotensive volunteers (83 men, 32 women) and radial artery waveforms obtained with the use of a calibrated tonometer device in 212 healthy volunteers (147 women, 65 men). A computer-based assessment of the diastolic pressure decay and a modified Windkessel model of the circulation were used to quantify changes in arterial waveform morphology in terms of large artery or capacitive compliance, oscillatory or reflective compliance in the small arteries, inertance, and systemic vascular resistance. Large artery compliance and oscillatory compliance correlated negatively with age for both invasive and noninvasive groups (r=-0.50 and r=-0.55; r=-0.37 and r=-0.66; P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.33.6.1392