Local intramural heparin delivery during primary angioplasty for acute myocardial infarction: results of the Local PAMI Pilot Study

The feasibility and safety of local heparin delivery during acute infarct angioplasty was evaluated in a prospective, multicenter, 120-patient series. Angioplasty was performed using standard techniques, after which heparin (4,000 U) was delivered locally; 25% of patients received stents. Procedural...

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Bibliographic Details
Published in:Catheterization and cardiovascular interventions 1999-06, Vol.47 (2), p.237-242
Main Authors: Esente, P, Kaplan, A V, Ford, J K, Martin, J L, Ayres, M, Kosinski, E J, Lasorda, D M, Graham, M, Gallant, P, Grines, L L, Grines, C L
Format: Article
Language:English
Subjects:
Aged
Angioplasty, Balloon, Coronary
Feasibility Studies
Female
Fibrinolytic Agents - administration & dosage
Heparin - administration & dosage
Humans
Infusions, Intra-Arterial
Male
Middle Aged
Myocardial Infarction - therapy
Pilot Projects
Prospective Studies
Stents
Treatment Outcome
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Summary:The feasibility and safety of local heparin delivery during acute infarct angioplasty was evaluated in a prospective, multicenter, 120-patient series. Angioplasty was performed using standard techniques, after which heparin (4,000 U) was delivered locally; 25% of patients received stents. Procedural success was reported in 98% of patients; 6.7% of patients suffered death, reinfarction, recurrent ischemia, or stroke during the index hospitalization. The 6-month target vessel revascularization rate was 12.5%. Local heparin therapy with provisional stenting in acute myocardial infarction patients is safe, feasible, associated with a low rate of infarct artery revascularization at 6 months, and may potentially eliminate the need for systemic heparin following the procedure.
ISSN:1522-1946
DOI:10.1002/(SICI)1522-726X(199906)47:2<237::AID-CCD24>3.0.CO;2-S