Computational protein design

A ‘protein design cycle’, involving cycling between theory and experiment, has led to recent advances in rational protein design. A reductionist approach, in which protein positions are classified by their local environments, has aided development of an appropriate energy expression. The computation...

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Bibliographic Details
Published in:Structure 1999-05, Vol.7 (5), p.R105-R109
Main Authors: Street, Arthur G, Mayo, Stephen L
Format: Article
Language:English
Subjects:
Algorithms
biochemistry
Protein Conformation
Proteins - chemistry
structural biology
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Summary:A ‘protein design cycle’, involving cycling between theory and experiment, has led to recent advances in rational protein design. A reductionist approach, in which protein positions are classified by their local environments, has aided development of an appropriate energy expression. The computational principles and practicalities of the protein design cycle are discussed.
ISSN:0969-2126
1878-4186
DOI:10.1016/S0969-2126(99)80062-8