Antithrombogenic and antiplatelet activity of optho-isobornyl phenol derivative

We studied antithrombogenic and antiplatelet properties of 4-methyl-2,6-diisobornyl phenol, a new promising compound belonging to ortho-isobornyl phenol derivatives, under conditions of intravascular thrombosis and acute cerebral ischemia. It was found that 4-methyl-2,6-diisobornyl phenol prevents i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-03, Vol.145 (3), p.328-330
Main Authors: Plotnikov, M. B., Smolyakova, V. I., Ivanov, I. S., Kuchin, A. V., Chukicheva, I. J., Krasnov, E. A.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Bornanes - pharmacology
Brain Ischemia - drug therapy
Cell Biology
Cresols - pharmacology
Fibrinolytic Agents - therapeutic use
Internal Medicine
Laboratory Medicine
Male
Pathology
Pentoxifylline - therapeutic use
Pharmacology and Toxicology
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - therapeutic use
Rats
Rats, Wistar
Thrombosis - drug therapy
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Summary:We studied antithrombogenic and antiplatelet properties of 4-methyl-2,6-diisobornyl phenol, a new promising compound belonging to ortho-isobornyl phenol derivatives, under conditions of intravascular thrombosis and acute cerebral ischemia. It was found that 4-methyl-2,6-diisobornyl phenol prevents intravascular thrombus formation by reducing platelet aggregation and improving antiplatelet activity of the vascular wall.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0082-x