Biondi ring tangles in the choroid plexus of Alzheimer's disease and normal aging brains: a quantitative study

The choroid plexus (CP) performs the vital function of producing up to 90% (450–1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However,...

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Bibliographic Details
Published in:Brain research 1999-06, Vol.832 (1-2), p.40-46
Main Authors: Wen, Guang Y., Wisniewski, Henryk M., Kascsak, Richard J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Aging - pathology
Alzheimer Disease - pathology
Alzheimer's disease
Biological and medical sciences
Biondi ring tangle
Case-Control Studies
Cerebral Ventricles - pathology
Choroid plexus
Choroid Plexus - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Inclusion Bodies - pathology
Infant
Male
Medical sciences
Microscopy, Electron
Microscopy, Fluorescence
Middle Aged
Neurofibrillary Tangles - pathology
Neurology
Staining and Labeling
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Summary:The choroid plexus (CP) performs the vital function of producing up to 90% (450–1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of intracellular inclusions called Biondi ring tangles (BRTs) in CP cells of Alzheimer's disease (AD)/aging brains may affect these vital functions of the CP. Statistical analysis of quantitative data on the numbers of CP cells containing BRTs from 54 brains (29 AD and 25 normal control), age range 1–100 years, indicated a significant difference (p
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(99)01466-3