Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India

We have investigated the clinical, hematological, and molecular genetic characteristics of sickle cell anemia patients from 6 populations of Andhra Pradesh, South India. Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 t...

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Published in:Human biology 1999-06, Vol.71 (3), p.333-340
Main Authors: NIRANJAN, Y., CHANDAK, G.R., VEERRAJU, P., SINGH, LALJI
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anemia, Sickle Cell - ethnology
Anemia, Sickle Cell - genetics
Base Sequence
Blood
Child
Child, Preschool
Chromosomes
Developing Countries
European Continental Ancestry Group - genetics
Female
Gene Expression
Genes
Genetic aspects
Genetic mutation
Genetics
Genetics, Population
Haplotypes
Haplotypes - genetics
Health aspects
Health risk assessment
Hemoglobins
Hemoglobins - analysis
Hemoglobins - genetics
Human genetics
Humans
India - epidemiology
Male
Medical genetics
Molecular Sequence Data
Polymerase Chain Reaction
Population
Population Surveillance
Rural Population
Sampling Studies
Saudi Arabia - ethnology
Senegal - ethnology
Sickle cell anemia
Sickles
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container_end_page 340
container_issue 3
container_start_page 333
container_title Human biology
container_volume 71
creator NIRANJAN, Y.
CHANDAK, G.R.
VEERRAJU, P.
SINGH, LALJI
description We have investigated the clinical, hematological, and molecular genetic characteristics of sickle cell anemia patients from 6 populations of Andhra Pradesh, South India. Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 to a Bantu haplotype, 2 to a Cameroon haplotype, and 3 to rare haplotypes. This is the first report of a Bantu haplotype in an Indian population. Some information on haplotype characteristics of normal chromosomes (HBB*A) is also presented. The average hemoglobin level was 7.3 g% and mean fetal hemoglobin (HbF) level was 12.6%. The higher HbF levels corroborate earlier observations in sickle cell homozygotes from India. Clinical investigations have revealed splenomegaly and painful crises as the most common features in these patients.
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Of 72 sickle cell chromosomes (HBB*S) 60 belong to characteristic Arab-Indian haplotypes, 6 to variant Arab-Indian haplotypes, 1 to a Bantu haplotype, 2 to a Cameroon haplotype, and 3 to rare haplotypes. This is the first report of a Bantu haplotype in an Indian population. Some information on haplotype characteristics of normal chromosomes (HBB*A) is also presented. The average hemoglobin level was 7.3 g% and mean fetal hemoglobin (HbF) level was 12.6%. The higher HbF levels corroborate earlier observations in sickle cell homozygotes from India. 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subjects Adolescent
Adult
Anemia, Sickle Cell - ethnology
Anemia, Sickle Cell - genetics
Base Sequence
Blood
Child
Child, Preschool
Chromosomes
Developing Countries
European Continental Ancestry Group - genetics
Female
Gene Expression
Genes
Genetic aspects
Genetic mutation
Genetics
Genetics, Population
Haplotypes
Haplotypes - genetics
Health aspects
Health risk assessment
Hemoglobins
Hemoglobins - analysis
Hemoglobins - genetics
Human genetics
Humans
India - epidemiology
Male
Medical genetics
Molecular Sequence Data
Polymerase Chain Reaction
Population
Population Surveillance
Rural Population
Sampling Studies
Saudi Arabia - ethnology
Senegal - ethnology
Sickle cell anemia
Sickles
title Some Atypical and Rare Sickle Cell Gene Haplotypes in Populations of Andhra Pradesh, India
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