The significance of high levels of lipoprotein (a) compared with established risk factors in premature coronary artery disease: differences between men and women

It was shown in a series of studies that increased lipoprotein (a) concentration is a strong and independent risk factor for coronary artery disease. The goal of this study was to determine the significance of elevated lipoprotein (a) levels for the existence and the early manifestation of coronary...

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Published in:Atherosclerosis 1999-05, Vol.144 (1), p.221-228
Main Authors: Hahmann, Harry W., Schätzer-Klotz, Dorothea, Bunte, Thomas, Becker, Dieter, Schieffer, Hermann J.
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Age of Onset
Aged
Biological and medical sciences
Biomarkers - analysis
Cardiology. Vascular system
Coronary Angiography
Coronary artery disease
Coronary Disease - blood
Coronary Disease - diagnosis
Coronary Disease - epidemiology
Coronary heart disease
Early atherosclerosis
Female
Germany - epidemiology
Heart
Humans
Lipoprotein (a)
Lipoprotein(a) - blood
Lipoprotein(a) - metabolism
Male
Medical sciences
Middle Aged
Risk Factors
Risk factors in women
Sensitivity and Specificity
Sex Distribution
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container_issue 1
container_start_page 221
container_title Atherosclerosis
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creator Hahmann, Harry W.
Schätzer-Klotz, Dorothea
Bunte, Thomas
Becker, Dieter
Schieffer, Hermann J.
description It was shown in a series of studies that increased lipoprotein (a) concentration is a strong and independent risk factor for coronary artery disease. The goal of this study was to determine the significance of elevated lipoprotein (a) levels for the existence and the early manifestation of coronary artery disease by systematically recording cardiovascular risk factors in diagnostic coronary angiographies in a larger group of patients, whereby particular attention was paid to sex-specific differences. In 1011 consecutive patients who underwent coronary angiography (731 men, 280 women, mean age 59±10 years), fasting blood samples were taken immediately before the angiographies to determine the levels of cholesterol, low density lipoprotein-, high density lipoprotein-cholesterol, triglycerides and lipoprotein (a). In addition, further risk factors were qualitatively recorded. The data evaluation was carried out using the SPSSx software package univariately and multivariately with stepwise discriminant analysis. In 231 patients (144 men, 87 women) either no or only discrete coronary findings appeared, while in 780 cases (587 men, 193 women) coronary artery disease with stenoses >50% were found. Women with coronary artery disease were significantly older than men and demonstrated higher lipoprotein levels. Women as well as men with coronary artery disease differed from healthy controls by having higher levels of lipoprotein (a) and other lipoproteins, lipoprotein (a) having the smallest error probability ( P
doi_str_mv 10.1016/S0021-9150(99)00057-X
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The goal of this study was to determine the significance of elevated lipoprotein (a) levels for the existence and the early manifestation of coronary artery disease by systematically recording cardiovascular risk factors in diagnostic coronary angiographies in a larger group of patients, whereby particular attention was paid to sex-specific differences. In 1011 consecutive patients who underwent coronary angiography (731 men, 280 women, mean age 59±10 years), fasting blood samples were taken immediately before the angiographies to determine the levels of cholesterol, low density lipoprotein-, high density lipoprotein-cholesterol, triglycerides and lipoprotein (a). In addition, further risk factors were qualitatively recorded. The data evaluation was carried out using the SPSSx software package univariately and multivariately with stepwise discriminant analysis. 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The most striking finding was that in young women (&lt;53 years), compared to older women with coronary artery disease—corresponding to the age-determined prevalence—significantly lower concentrations of cholesterol, triglycerides and lipoprotein (a) were found. Possible explanations include later manifestation of coronary artery disease, a steeper increase of the lipids with age, particularly of lipoprotein (a), but also a different valence of the risk factors in women.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(99)00057-X</identifier><identifier>PMID: 10381295</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adult ; Age Distribution ; Age of Onset ; Aged ; Biological and medical sciences ; Biomarkers - analysis ; Cardiology. 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The goal of this study was to determine the significance of elevated lipoprotein (a) levels for the existence and the early manifestation of coronary artery disease by systematically recording cardiovascular risk factors in diagnostic coronary angiographies in a larger group of patients, whereby particular attention was paid to sex-specific differences. In 1011 consecutive patients who underwent coronary angiography (731 men, 280 women, mean age 59±10 years), fasting blood samples were taken immediately before the angiographies to determine the levels of cholesterol, low density lipoprotein-, high density lipoprotein-cholesterol, triglycerides and lipoprotein (a). In addition, further risk factors were qualitatively recorded. The data evaluation was carried out using the SPSSx software package univariately and multivariately with stepwise discriminant analysis. In 231 patients (144 men, 87 women) either no or only discrete coronary findings appeared, while in 780 cases (587 men, 193 women) coronary artery disease with stenoses &gt;50% were found. Women with coronary artery disease were significantly older than men and demonstrated higher lipoprotein levels. Women as well as men with coronary artery disease differed from healthy controls by having higher levels of lipoprotein (a) and other lipoproteins, lipoprotein (a) having the smallest error probability ( P&lt;0.0005). The early manifestation of coronary artery disease (below the 18th age percentile) in men (&lt;50 years) was connected with significantly higher levels of cholesterol, triglycerides and lipoprotein (a), which emphasized their atherogenic significance in the general view. The most striking finding was that in young women (&lt;53 years), compared to older women with coronary artery disease—corresponding to the age-determined prevalence—significantly lower concentrations of cholesterol, triglycerides and lipoprotein (a) were found. Possible explanations include later manifestation of coronary artery disease, a steeper increase of the lipids with age, particularly of lipoprotein (a), but also a different valence of the risk factors in women.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>10381295</pmid><doi>10.1016/S0021-9150(99)00057-X</doi><tpages>8</tpages></addata></record>
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subjects Adult
Age Distribution
Age of Onset
Aged
Biological and medical sciences
Biomarkers - analysis
Cardiology. Vascular system
Coronary Angiography
Coronary artery disease
Coronary Disease - blood
Coronary Disease - diagnosis
Coronary Disease - epidemiology
Coronary heart disease
Early atherosclerosis
Female
Germany - epidemiology
Heart
Humans
Lipoprotein (a)
Lipoprotein(a) - blood
Lipoprotein(a) - metabolism
Male
Medical sciences
Middle Aged
Risk Factors
Risk factors in women
Sensitivity and Specificity
Sex Distribution
title The significance of high levels of lipoprotein (a) compared with established risk factors in premature coronary artery disease: differences between men and women
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