Virus-encoded modulators of cytokines and growth factors

In the last three years, a surprising amount of data have been generated on virus-encoded immunomodulating genes. There are now elegant examples of viral interference with virtually every aspect of both the innate and adaptive immune response, including cytotoxic T lymphocyte, natural killer cell an...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 1999-03, Vol.10 (1), p.1-4
Main Author: Spriggs, Melanie K
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adjuvants, Immunologic - genetics
Animals
Antibody Formation
Cytokines - antagonists & inhibitors
Cytokines - immunology
Genes, Viral
Genetic Code
Growth Substances - immunology
Humans
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Summary:In the last three years, a surprising amount of data have been generated on virus-encoded immunomodulating genes. There are now elegant examples of viral interference with virtually every aspect of both the innate and adaptive immune response, including cytotoxic T lymphocyte, natural killer cell and B cell function, MHC class I expression, apoptosis, complement fixation, chemokine and interferon activity. Where large amounts of data accumulate, review articles are sure to follow, and several excellent reviews on the above topics are recommended. This review is not intended to be comprehensive; rather, it seeks to highlight recent examples of virus-encoded cytokines, growth factors and their receptors.
ISSN:1359-6101
DOI:10.1016/S1359-6101(98)00021-5