Effect of cranberry extracts on lipid profiles in subjects with Type 2 diabetes

• Published in: Diabetic medicine 2008-12, Vol.25 (12), p.1473-1477
• Main Authors: Lee, I. T., Chan, Y. C., Lin, C. W., Lee, W. J., Sheu, W. H-H.
• Format: Article
• Language: English
• Subjects: Aged; Biological and medical sciences; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Humans; Lipid Metabolism - drug effects; lipids; Male; Medical sciences; Phytotherapy; Plant Extracts - pharmacology; randomized controlled trial; Risk Factors; Type 2 diabetes; Vaccinium macrocarpon; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2008.02588.x

Aim  To examine the effect of cranberry ingestion on lipid profiles in Type 2 diabetic patients taking oral glucose‐lowering drugs. Methods  Thirty Type 2 diabetic subjects (16 males and 14 females; mean age 65 ± 1 years) who were taking oral glucose‐lowering medication regularly were enrolled in this randomized, placebo‐controlled, double‐blind study. Changes in lipid profiles, oxidized low‐density lipoprotein (ox‐LDL), glycaemic control, components of the metabolic syndrome, C‐reactive protein (CRP) and urinary albumin excretion (UAE) were assessed after cranberry or placebo treatment for 12 weeks. Results  Low‐density lipoprotein (LDL) cholesterol decreased significantly in the cranberry group (from 3.3 ± 0.2 to 2.9 ± 0.2 mmol/l, P = 0.005) and the decrease was significantly greater than that in the placebo group (–0.4 ± 0.1 vs. 0.2 ± 0.1 mmol/l, P