Cloning and sequence comparison of sheep CD28 and CTLA-4

T cells express CD28 and CTLA-4 and through binding to their shared ligands (CD80/86) on antigen presenting cells, they provide important co-stimulatory signals involved in T-cell activation. Although CD28 and CTLA-4 are related glycoproteins they appear to have different roles, with CD28 providing...

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Bibliographic Details
Published in:Immunogenetics (New York) 1999-06, Vol.49 (6), p.583-584
Main Authors: Chaplin, P J, Pietrala, L N, Scheerlinck, J P
Format: Article
Language:English
Subjects:
Abatacept
Amino Acid Sequence
Animals
Antigens, CD
Antigens, Differentiation - genetics
Base Sequence
Cattle
CD28 Antigens - genetics
Cloning, Molecular
CTLA-4 Antigen
DNA, Complementary
Humans
Immunoconjugates
Molecular Sequence Data
Sequence Analysis, DNA
Sheep
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Summary:T cells express CD28 and CTLA-4 and through binding to their shared ligands (CD80/86) on antigen presenting cells, they provide important co-stimulatory signals involved in T-cell activation. Although CD28 and CTLA-4 are related glycoproteins they appear to have different roles, with CD28 providing a stimulatory signal, while CTLA-4 is associated with a suppressive or down regulatory signal. A greater understanding of the functions of CD28 and CTLA-4 may allow for future immune intervention by enhancing or suppressing the immune response generated by pathogens or vaccines.
ISSN:0093-7711
1432-1211
DOI:10.1007/s002510050542