Bioassays for itraconazole blood levels : an interlaboratory collaborative study

Duplicate bioassays for itraconazole and hydroxy-itraconazole were run with 30 serum samples in five laboratories, each using a different method. Both itraconazole and hydroxy-itraconazole were used as standards. Despite quantitative variations, the results of the bioassays correlated sufficiently t...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1999-05, Vol.43 (5), p.723-727
Main Authors: ODDS, F. C, DUPONT, B, RINALDI, M. G, STEVENS, D. A, WARNOCK, D. W, WOESTENBORGHS, R
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - blood
Bioassays
Biological and medical sciences
Biological Assay - methods
Chromatography, High Pressure Liquid - methods
Humans
Itraconazole - analogs & derivatives
Itraconazole - blood
Medical sciences
Pharmacology. Drug treatments
Reproducibility of Results
Sensitivity and Specificity
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Description
Summary:Duplicate bioassays for itraconazole and hydroxy-itraconazole were run with 30 serum samples in five laboratories, each using a different method. Both itraconazole and hydroxy-itraconazole were used as standards. Despite quantitative variations, the results of the bioassays correlated sufficiently to indicate the relative level of antifungal activity in the test samples.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/43.5.723