Atypical furunculosis vaccines for Atlantic cod ( Gadus morhua ); vaccine efficacy and antibody responses

Abstract Atypical furunculosis caused by atypical Aeromonas salmonicida , is an emerging problem in farming of Atlantic cod ( Gadus morhua ) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing in surface antigens such as the A-layer prote...

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Bibliographic Details
Published in:Vaccine 2008-12, Vol.26 (52), p.6791-6799
Main Authors: Lund, Vera, Arnesen, Jan Arne, Mikkelsen, Helene, Gravningen, Kjersti, Brown, Laura, Schrøder, Merete B
Format: Article
Language:English
Subjects:
A-protein
Adjuvants, Immunologic
Aeromonas salmonicida
Aeromonas salmonicida - genetics
Aeromonas salmonicida - immunology
Allergy and Immunology
Animals
Antibodies, Bacterial - analysis
Antibodies, Bacterial - biosynthesis
Antibodies, Bacterial - immunology
Antibody response
Antigens
Applied microbiology
Atlantic cod
Atypical furunculosis
Bacterial Vaccines - genetics
Bacterial Vaccines - immunology
Bacterial Vaccines - therapeutic use
Bacteriology
Biological and medical sciences
Blotting, Western
Chemistry, Pharmaceutical
Cod
Enzyme-Linked Immunosorbent Assay
Experiments
Fish
Fish Diseases - immunology
Fish Diseases - microbiology
Fish Diseases - prevention & control
Fundamental and applied biological sciences. Psychology
Furunculosis - immunology
Furunculosis - prevention & control
Furunculosis - veterinary
Gadus morhua
Gadus morhua - immunology
Infections
Lipopolysaccharides
Lipopolysaccharides - immunology
Microbiology
Miscellaneous
Proteins
Salmon
Studies
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virulence
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Summary:Abstract Atypical furunculosis caused by atypical Aeromonas salmonicida , is an emerging problem in farming of Atlantic cod ( Gadus morhua ) in Norway, and vaccines are needed. Atypical A. salmonicida comprises a heterogeneous group of bacteria differing in surface antigens such as the A-layer protein and lipopolysaccharides (LPS). Except for one of the experimental oil-adjuvanted whole cell vaccines based on various isolates they all resulted in moderate protection. No clear correlation between vaccine efficacies and the A-protein group or LPS type of the vaccine isolates was revealed, while a correlation between efficacy and the presence of cross-reacting LPS-specific antibodies is indicated.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2008.10.012