Isolation and characterization of new limonoid glycosides from Citrus unshiu peels

Three limonoid glycosides were isolated from Citrus unshiu peels, and their structures were determined based on MS and NMR spectroscopic data as nomilinic acid 17- O-β- d-glucopyranoside ( 1), methyl nomilinate 17- O-β- d-glucopyranoside ( 2), and obacunone 17- O-β- d-glucopyranoside ( 3). In partic...

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Bibliographic Details
Published in:Carbohydrate research 1999-01, Vol.315 (1), p.142-147
Main Authors: Sawabe, Akiyoshi, Morita, Masanori, Kiso, Tatsuya, Kishine, Hideki, Ohtsubo, Yoshikazu, Minematsu, Toshie, Matsubara, Yoshiharu, Okamoto, Tadashi
Format: Article
Language:English
Subjects:
Animals
B/ E constant linked scan FABMS
Carbohydrate Sequence
chemical constituents of plants
Citrus - chemistry
Citrus unshiu
Drug Screening Assays, Antitumor
Glycosides - chemistry
Glycosides - isolation & purification
Humans
Limonoid glycosides
limonoids
Magnetic Resonance Spectroscopy
Methyl nomilinate 17- O-β- d-glucopyranoside
Mice
Molecular Sequence Data
peel
Tumor Cells, Cultured
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Summary:Three limonoid glycosides were isolated from Citrus unshiu peels, and their structures were determined based on MS and NMR spectroscopic data as nomilinic acid 17- O-β- d-glucopyranoside ( 1), methyl nomilinate 17- O-β- d-glucopyranoside ( 2), and obacunone 17- O-β- d-glucopyranoside ( 3). In particular, the location of the sugar moiety was clearly determined by the B/E constant linked scan FABMS method. No limonoid glycosides obtained here were found to have antitumor activity in NCI-H292 and EL-4 cell lines.
ISSN:0008-6215
1873-426X
DOI:10.1016/S0008-6215(98)00328-0