Synthesis, Characterization, and Antifungal Activity of Boron-Containing Thiosemicarbazones

Addition of thiosemicarbazide, 4‐allylthiosemicarbazide, and 4‐phenylthiosemicarbazide to (formylphenyl)boronic acids affords a series of thiosemicarbazones containing boronic acids. Addition of 2‐formylphenylboronic acid to the thiosemicarbazides gave the corresponding cyclic 2,3,1‐benzodiazaborine...

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Bibliographic Details
Published in:Chemistry & biodiversity 2008-11, Vol.5 (11), p.2415-2422
Main Authors: Hicks, Justin W., Kyle, Christian B., Vogels, Christopher M., Wheaton, Susan L., Baerlocher, Felix J., Decken, Andreas, Westcott, Stephen A.
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Boron compounds
Boronic acids
Diazaborines
Microbial Sensitivity Tests
Thiosemicarbazones
Thiosemicarbazones - chemical synthesis
Thiosemicarbazones - chemistry
Thiosemicarbazones - pharmacology
X-Ray crystallography
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Summary:Addition of thiosemicarbazide, 4‐allylthiosemicarbazide, and 4‐phenylthiosemicarbazide to (formylphenyl)boronic acids affords a series of thiosemicarbazones containing boronic acids. Addition of 2‐formylphenylboronic acid to the thiosemicarbazides gave the corresponding cyclic 2,3,1‐benzodiazaborines. All new compounds have been investigated for potential antifungal activity.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.200890206