Spleen localization of light chain deposition disease associated with sea blue histiocytosis, revealed by spontaneous rupture

Splenic involvement by a light chain deposition disease (LCDD) associated with sea-blue histiocytosis occurred in a 55-year-old man presenting with LCDD of the kidney without myeloma. Lambda light chain deposits were demonstrated by immunohistochemistry in vessel walls and along the ring fibres of t...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 1999-05, Vol.434 (5), p.463-465
Main Authors: DE LAJARTE-THIROUARD, A. S, MOLINA, T, AUDOUIN, J, LE TOURNEAU, A, LEDUC, F, ROSE, C, DIEBOLD, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Hematologic and hematopoietic diseases
Humans
Immunoglobulin Light Chains - metabolism
Male
Medical sciences
Middle Aged
Other diseases. Hematologic involvement in other diseases
Paraproteinemias - complications
Paraproteinemias - metabolism
Paraproteinemias - pathology
Rupture, Spontaneous
Sea-Blue Histiocyte Syndrome - complications
Sea-Blue Histiocyte Syndrome - metabolism
Sea-Blue Histiocyte Syndrome - pathology
Spleen - metabolism
Spleen - pathology
Splenic Rupture - etiology
Splenic Rupture - metabolism
Splenic Rupture - pathology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Splenic involvement by a light chain deposition disease (LCDD) associated with sea-blue histiocytosis occurred in a 55-year-old man presenting with LCDD of the kidney without myeloma. Lambda light chain deposits were demonstrated by immunohistochemistry in vessel walls and along the ring fibres of the red pulp sinuses. Accumulation of sea blue histiocytes in the cords was also present. Stiffness of the walls of the red pulp sinuses resulting from light chain deposits may have induced accumulation and destruction of circulating blood cells. Lipid catabolism with production of ceroids may have resulted in lipidic histiocytosis with a sea blue histiocyte pattern.
ISSN:0945-6317
1432-2307
DOI:10.1007/s004280050368