The novel transmembrane Escherichia coli proteins involved in the amino acid efflux

A novel gene of Escherichia coli, rhtB, has been characterized. Amplification of this gene provides resistance to homoserine and homoserine lactone. Another E. coli gene, rhtC, provides resistance to threonine. The homologues of RhtB are widely distributed among various eubacteria and archaea, from...

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Bibliographic Details
Published in:FEBS letters 1999-06, Vol.452 (3), p.228-232
Main Authors: Zakataeva, Natalia P., Aleshin, Vladimir V., Tokmakova, Irina L., Troshin, Petr V., Livshits, Vitaliy A.
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - metabolism
Amino Acids - metabolism
Archaea - genetics
Archaea - metabolism
Chromosomes, Bacterial
Cloning, Molecular
Efflux
Escherichia coli - genetics
Escherichia coli - metabolism
Genes, Bacterial
Homoserine
Homoserine - metabolism
Membrane Proteins - genetics
Membrane Proteins - metabolism
Phenotype
Restriction Mapping
Threonine
Threonine - metabolism
Transmembrane protein
Transport
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Summary:A novel gene of Escherichia coli, rhtB, has been characterized. Amplification of this gene provides resistance to homoserine and homoserine lactone. Another E. coli gene, rhtC, provides resistance to threonine. The homologues of RhtB are widely distributed among various eubacteria and archaea, from one to 12 copies of family members that differ in their primary structure were found in the genomes. Most of them are genes that encode hypothetical transmembrane proteins. Experimental data that indicate participation of the rhtB product in the excretion of homoserine have been obtained.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00625-0