Deep vein thrombosis in elderly Hong Kong Chinese with hip fractures detected with compression ultrasound and Doppler imaging : incidence and effect of low molecular weight heparin

• Published in: Archives of orthopaedic and trauma surgery 1999-05, Vol.119 (3-4), p.156-158
• Main Authors: KEW, J, LEE, Y. L, DAVEY, I. C, HO, S. Y, FUNG, K. C, METREWELI, C
• Format: Article
• Language: English
• Subjects: Aged; Anticoagulants; Anticoagulants - therapeutic use; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; China - ethnology; Double-Blind Method; Fractures; Health risk assessment; Heparin, Low-Molecular-Weight - therapeutic use; Hip Fractures - surgery; Hong Kong - epidemiology; Humans; Incidence; Medical sciences; Molecular weight; Pharmacology. Drug treatments; Postoperative Complications - diagnostic imaging; Postoperative Complications - epidemiology; Postoperative Complications - prevention & control; Prospective Studies; Thrombosis; Ultrasonic imaging; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Pulsed; Venous Thrombosis - diagnostic imaging; Venous Thrombosis - epidemiology; Venous Thrombosis - etiology
• ISSN: 0936-8051; 1434-3916
• DOI: 10.1007/s004020050380

Seventy-eight patients of average age 78 years suffering from an unilateral non-pathological hip fracture underwent compression ultrasound and pulsed and colour Doppler examination of both legs. Twenty-three patients were randomly placed on low molecular weight heparin (LMWH). Twenty-nine (37%) suffered deep venous thrombosis (DVT). There was no statistically significant difference in the incidence of DVT between the control and LMWH groups, and the incidence of DVT in elderly Chinese patients after hip replacement for a hip fracture is similar to that in other studies in Caucasians. There were, however, some differences, namely the contiguous nature of the thrombi rather than focal segmental clots, and the absence of propagation or tail formation. Although the numbers are small, this could possibly represent a population difference. There was a significantly increased occurrence of DVTs on the operated side in both groups. Serial ultrasound examination supports evidence that DVTs occur in the 1st week postoperatively, but there were also a number of patients who developed DVTs in the 2nd week. There was no statistically significant difference in overall incidence of DVT between patients on prophylactic heparin and the control group. Patients on prophylactic heparin had no thigh DVTs in comparison to the control group. LMWH may thus be effective in preventing thigh DVTs and pulmonary emboli.