Bioactive sesquiterpenes from Santolina rosmarinifolia subsp. Canescens. A conformational analysis of the germacrane ring

The hexane extract of aerial parts of Santolina rosmarinifolia subsp. canescens afforded eight new sesquiterpenes in addition to known compounds. Their structures were determined by spectroscopic methods and chemical transformations. The conformational analysis of the germacrane constituents was car...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 1999-06, Vol.51 (4), p.529-541
Main Authors: Barrero, Alejandro F., Herrador, M.Mar, Quilez, Jose F., Alvarez-Manzaneda, Ramon, Portal, Dolores, Gavin, Jose A., Gravalos, Dolores G., Simmonds, M.S.J., Blaney, W.M.
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
Antifeedants
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Asteraceae - chemistry
Biological activities
Biological and medical sciences
Chemical constitution
Chemical control
Compositae
Conformational study
Control
Drug Screening Assays, Antitumor
Fundamental and applied biological sciences. Psychology
General pharmacology
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Medical sciences
Mice
Microbial Sensitivity Tests
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytopathology. Animal pests. Plant and forest protection
Plant physiology and development
Protozoa. Invertebrates
Santolina rosmarinifolia subsp. canescens
Sesquiterpenes
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Tumor Cells, Cultured
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Summary:The hexane extract of aerial parts of Santolina rosmarinifolia subsp. canescens afforded eight new sesquiterpenes in addition to known compounds. Their structures were determined by spectroscopic methods and chemical transformations. The conformational analysis of the germacrane constituents was carried out by spectroscopic methods, including NMR at varying temperature and by molecular mechanics calculations. The antifeedant, antibacterial and antitumoral activity of selected compounds has been tested.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(99)00047-3