Immunity to airborne challenge with Venezuelan equine encephalitis virus develops rapidly after immunisation with the attenuated vaccine strain TC-83

Mice vaccinated subcutaneously with the attenuated vaccine strain of Venezuelan equine encephalitis virus (VEEV) rapidly develop immunity to subcutaneous or airborne challenge with virulent VEEV. The specificity of this immune response was demonstrated by challenge with a heterologous virus (St. Lou...

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Bibliographic Details
Published in:Vaccine 1999-05, Vol.17 (19), p.2429-2435
Main Author: Phillpotts, R.J
Format: Article
Language:English
Subjects:
Administration, Intranasal
Airborne infection
Animals
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
Antibody Specificity
Biological and medical sciences
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - virology
Encephalitis Virus, Venezuelan Equine - immunology
Encephalomyelitis, Venezuelan Equine - immunology
Female
Fundamental and applied biological sciences. Psychology
Mice
Mice, Inbred BALB C
Microbiology
Neutralization Tests
Vaccine
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - immunology
Venezuelan equine encephalitis virus
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
Virology
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Summary:Mice vaccinated subcutaneously with the attenuated vaccine strain of Venezuelan equine encephalitis virus (VEEV) rapidly develop immunity to subcutaneous or airborne challenge with virulent VEEV. The specificity of this immune response was demonstrated by challenge with a heterologous virus (St. Louis encephalitis virus). Examination of the levels of VEEV-specific antibody classes in serum and respiratory secretions suggested that the rapid development of immunity was coincident with the appearance of specific IgM and IgG (but not IgA) in the respiratory tract. In order to confirm the role of respiratory tract antibody, mice were passively immunised either intraperitoneally or intranasally with polyclonal VEEV-specific IgG. Intranasal administration of specific IgG significantly enhanced protection against airborne challenge. These results confirm the need to emphasise local antibody production in the development of improved VEEV vaccines.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00022-5