The "Thrifty Genotype" in 1998

Neel compares and contrasts facts concerning the genetic bases for obesity, hypertension and type II diabetes or non-insulin-dependent diabetes mellitus (NIDDM) and their pathophysiology. The implications these facts could have for genetic and gene therapy are briefly discussed.

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Bibliographic Details
Published in:Nutrition reviews 1999-05, Vol.57 (5), p.2-9
Main Author: Neel, James V.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Diabetes
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - therapy
Diet
Fundamental and applied biological sciences. Psychology
Genetic Therapy
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Human
Humans
Hypertension
Indians, North American
Indians, South American
Insulin
Life Style
Obesity
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Description
Summary:Neel compares and contrasts facts concerning the genetic bases for obesity, hypertension and type II diabetes or non-insulin-dependent diabetes mellitus (NIDDM) and their pathophysiology. The implications these facts could have for genetic and gene therapy are briefly discussed.
ISSN:0029-6643
1753-4887
DOI:10.1111/j.1753-4887.1999.tb01782.x