Synchronous Metastatic Melanoma Presenting as Gingival and Facial Swelling: A Case Report and Review of the Literature

Background: Metastases to the oral cavity are unusual, and most cases affect the jaws. The clinicopathologic features of a metastatic melanoma involving the mandibular gingiva and facial skin are described. Methods: A 42‐year‐old white woman who had been treated for plantar melanoma 10 years ago sho...

Full description

Saved in:
Bibliographic Details
Published in:Journal of periodontology (1970) 2008-12, Vol.79 (12), p.2371-2377
Main Authors: Bonan, Paulo Rogério Ferreti, Laranjeira, Anamaria Lima, Martelli‐Júnior, Hercílio, Guimarães, André Luiz Sena, Vargas, Pablo Agustín, Coletta, Ricardo D.
Format: Article
Language:English
Subjects:
Adult
Antigens, Neoplasm - analysis
Biological and medical sciences
Biopsy
Biopsy, Fine-Needle
Case report
Dentistry
Dermatology
Facial Neoplasms - secondary
facial skin
Fatal Outcome
Female
Foot Diseases - pathology
gingiva
Gingival Neoplasms - secondary
Humans
MART-1 Antigen
Medical sciences
melanoma
Melanoma - immunology
Melanoma - pathology
Melanoma - secondary
Melanoma-Specific Antigens
metastasis
Neoplasm Proteins - analysis
Otorhinolaryngology. Stomatology
S100 Proteins - analysis
Tomography, X-Ray Computed
Tumors of the skin and soft tissue. Premalignant lesions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Metastases to the oral cavity are unusual, and most cases affect the jaws. The clinicopathologic features of a metastatic melanoma involving the mandibular gingiva and facial skin are described. Methods: A 42‐year‐old white woman who had been treated for plantar melanoma 10 years ago showed concomitant nodular lesions in the mandibular gingiva and facial skin. Incisional biopsy and fine needle aspiration cytology were performed in the gingival and facial swelling, respectively. Results: Radiographs revealed irregular bone erosion and widening of the periodontal ligament space associated with the gingival lesion, whereas cranial computed tomography showed an irregular hyperdense mass associated with the dermal tissue. The histopathologic findings were suggestive of melanoma; immunohistochemical analysis revealed, in both lesions, neoplastic cells strongly positive for S100 and HMB‐45 antibodies and weak reactivity for melan‐A. The final diagnosis of these lesions was metastatic melanoma, and the patient died before restarting treatment. Conclusions: To the best of our knowledge, this is the first English‐language report of metastatic melanoma affecting the gingiva and facial skin concomitantly. The intraoral involvement of disseminated melanoma indicates a very poor prognosis, as confirmed by the current case.
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2008.080224