Diazaphilonic Acid, a New Azaphilone with Telomerase Inhibitory Activity

Through our screening program of bioactive secondary metabolites of microbial origin, we have isolated a new azaphilone-type metabolite, diazaphilonic acid (Fig. 1). In this paper, we report the taxonomy of the producing strain, production, isolation, physico-chemical properties and biological activ...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1999/04/25, Vol.52(4), pp.412-414
Main Authors: TABATA, YUJI, IKEGAMI, SHUJI, YAGUCHI, TAKASHI, SASAKI, TORU, HOSHIKO, SHIGERU, SAKUMA, SADATOSHI, SFFIN-YA, KAZUO, SETO, HARUO
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Ascomycota - chemistry
Benzopyrans - chemistry
Benzopyrans - isolation & purification
Benzopyrans - pharmacology
Biological and medical sciences
Carboxylic Acids - chemistry
Carboxylic Acids - isolation & purification
Carboxylic Acids - pharmacology
Chromatography, Gel
Chromatography, High Pressure Liquid
DNA - chemistry
DNA Primers - chemistry
Electrophoresis, Polyacrylamide Gel
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Fermentation
Fundamental and applied biological sciences. Psychology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Microbiology
Polymerase Chain Reaction
Telomerase - antagonists & inhibitors
Telomerase - chemistry
Yeasts - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Through our screening program of bioactive secondary metabolites of microbial origin, we have isolated a new azaphilone-type metabolite, diazaphilonic acid (Fig. 1). In this paper, we report the taxonomy of the producing strain, production, isolation, physico-chemical properties and biological activities of diazaphilonic acid.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.52.412