Pathophysiology of atrial fibrillation: Insights into the renin–angiotensin system

Summary Introduction Atrial fibrillation is, to date, a major problem of public health with an important cost in the health care system. Discussion The therapeutic strategies for atrial fibrillation are complex and their outcomes have been disappointing globally. New ablative techniques have brought...

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Bibliographic Details
Published in:Archives of cardiovascular diseases 2008-11, Vol.101 (11), p.787-791
Main Authors: Le Heuzey, Jean-Yves, Marijon, Éloi, Chachoua, Karim, Waintraub, Xavier, Lepillier, Antoine, Otmani, Akli, Lavergne, Thomas, Pornin, Maurice
Format: Article
Language:English
Subjects:
Antagonistes de l’angiotensine II
Anti-Arrhythmia Agents - therapeutic use
Antihypertensive Agents - therapeutic use
Arterial hypertension. Arterial hypotension
Atherosclerosis (general aspects, experimental research)
Atrial fibrillation
Atrial Fibrillation - drug therapy
Atrial Fibrillation - etiology
Atrial Fibrillation - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiac dysrhythmias
Cardiology. Vascular system
Cardiovascular
Fibrillation atriale
Heart
Humans
Hypertension - complications
Hypertension - drug therapy
Hypertension - physiopathology
Hypertension artérielle
Inhibiteurs de l’enzyme de conversion
Internal Medicine
Medical sciences
Renin-Angiotensin System - drug effects
Renin–angiotensin system
Système rénine angiotensine
Treatment Outcome
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Summary:Summary Introduction Atrial fibrillation is, to date, a major problem of public health with an important cost in the health care system. Discussion The therapeutic strategies for atrial fibrillation are complex and their outcomes have been disappointing globally. New ablative techniques have brought important advances but the patient's profile has to be taken into account in the choice of the therapeutic strategies. The renin-angiotensin system plays a major role in the phenomena of remodelling following the onset of atrial fibrillation. Conclusion Drugs blocking the renin-angiotensin system can have a real place in the treatment of atrial fibrillation, not only to maintain sinus rhythm but primarily to prevent cardiovascular accidents in these patients with atrial fibrillation and in some cases to prevent the occurrence of atrial fibrillation, for example in hypertensive patients.
ISSN:1875-2136
1875-2128
DOI:10.1016/j.acvd.2008.09.015