Chronic fatigue stress leads to up-regulation of nitric oxide synthase in the rat nucleus accumbens

In the present study, the effect of chronic fatigue stress on the neuronal nitric oxide synthase (nNOS) in the rat nucleus accumbens (NAc) was assessed in order to explore the neurobiology mechanism of central fatigue stress, especially the role of the NAc in central fatigue. In the experiment, adul...

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Bibliographic Details
Published in:Scandinavian journal of medicine & science in sports 2008-12, Vol.18 (6), p.715-718
Main Authors: Liu, H.-Y., Jin, J., Tang, J.-S., Cui, J.-M.
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animals
Brain research
Chronic Disease
Chronic fatigue syndrome
Enzymes
exercise neurobiology
Fatigue - enzymology
Fatigue - physiopathology
fatigue stress
immunohistochemistry
neuronal nitric oxide synthase (nNOS)
Neurons
Nitric oxide
Nitric Oxide Synthase - metabolism
nucleus accumbens (NAc)
Nucleus Accumbens - enzymology
Physical Conditioning, Animal
Physical Exertion
Rats
Rats, Wistar
Rodents
swim
Up-Regulation - physiology
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Summary:In the present study, the effect of chronic fatigue stress on the neuronal nitric oxide synthase (nNOS) in the rat nucleus accumbens (NAc) was assessed in order to explore the neurobiology mechanism of central fatigue stress, especially the role of the NAc in central fatigue. In the experiment, adult male Wistar rats were forced to swim till exhaustion every day for 4 weeks. Immunohistochemistry was used for measurement of the nNOS‐positive neurons associated with the image manipulation. Our results showed that a long‐time exposure to chronic forced swim stress increased the number of nNOS immunoreactive‐positive neurons in the rat NAc (106.7%, P
ISSN:0905-7188
1600-0838
DOI:10.1111/j.1600-0838.2007.00722.x