Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity

Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp. multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated fl...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1999-06, Vol.62 (6), p.909-911
Main Authors: Aljancić, I, Vajs, V, Menković, N, Karadzić, I, Juranić, N, Milosavljević, S, Macura, S
Format: Article
Language:English
Subjects:
Achillea atrata multifida
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Asteraceae - chemistry
Bacillus subtilis
Candida albicans
Colony Count, Microbial
Escherichia coli
flavones
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Plant Stems - chemistry
Plants, Medicinal - chemistry
sesquiterpene lactones
Spectrophotometry, Ultraviolet
Yugoslavia
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Summary:Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp. multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.
ISSN:0163-3864
DOI:10.1021/np980536m