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Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity

Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp. multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated fl...

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 1999-06, Vol.62 (6), p.909-911
Main Authors:	Aljancić, I, Vajs, V, Menković, N, Karadzić, I, Juranić, N, Milosavljević, S, Macura, S
Format:	Article
Language:	English
Subjects:	Achillea atrata multifida Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Asteraceae - chemistry Bacillus subtilis Candida albicans Colony Count, Microbial Escherichia coli flavones Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plant Stems - chemistry Plants, Medicinal - chemistry sesquiterpene lactones Spectrophotometry, Ultraviolet Yugoslavia
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container_issue	6
container_start_page	909
container_title	Journal of natural products (Washington, D.C.)
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creator	Aljancić, I Vajs, V Menković, N Karadzić, I Juranić, N Milosavljević, S Macura, S
description	Four flavones (1-4) and nine sesquiterpene lactones (5-13), one of them (5) a new compound, were isolated from the aerial parts of Achillea atrata L. subsp. multifida. Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.
doi_str_mv	10.1021/np980536m
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Although the crude extract demonstrated in vitro inhibitory activity against Candida albicans and Bacillus subtilis, all isolated flavones were active against B. subtilis. Flavones 1, 2, and 3 were also active against C. albicans, while 1 and 3 exhibited activity against E. coli, as well. None of the tested lactones (7, 9, 12, and 13) showed any antimicrobial activity.</abstract><cop>United States</cop><pmid>10395518</pmid><doi>10.1021/np980536m</doi><tpages>3</tpages></addata></record>
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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Achillea atrata multifida Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Asteraceae - chemistry Bacillus subtilis Candida albicans Colony Count, Microbial Escherichia coli flavones Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Plant Stems - chemistry Plants, Medicinal - chemistry sesquiterpene lactones Spectrophotometry, Ultraviolet Yugoslavia
title	Flavones and sesquiterpene lactones from Achillea atrata subsp. multifida: antimicrobial activity
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