A CONSIDERATION ON THE RESULTS OF NATIONWIDE SURVEILLANCE OF ANTIMICROBIAL SUSCEPTIBILITIES: GRAM-NEGATIVE BACILLI

The results of the semi-annual nationwide surveillance of antimicrobial susceptibilities, conducted by the Japanese Ministry of Health and Welfare during the period of January 1993 to July 1995, were analyzed for typical Gram-negative bacilli in the purpose of provision of an index for antimicrobial...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of antibiotics 1999/04/25, Vol.52(4), pp.333-352
Main Authors: KUROYAMA, MASAKAZU, OKAMOTO, EMIKO, YAGO, KAZUO
Format: Article
Language:Japanese
Subjects:
Aminoglycosides
Anti-Bacterial Agents - pharmacology
Chloramphenicol - pharmacology
Drug Resistance, Microbial
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - isolation & purification
Humans
Japan
Lactams
Macrolides
Tetracyclines - pharmacology
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The results of the semi-annual nationwide surveillance of antimicrobial susceptibilities, conducted by the Japanese Ministry of Health and Welfare during the period of January 1993 to July 1995, were analyzed for typical Gram-negative bacilli in the purpose of provision of an index for antimicrobial selection. During these 3 years, Escherichia coli, Citrobacter freundii, Enterobacter aerogenes and Proteus mirabilisshowed slightly increasing tendency in susceptibility to fosfomycin (FOM) and Citrobacter freundii, Klebsiellapneumoniae and Enterobacter aerogenes showed slightly increasing tendency to minocycline (MINO). WhileHaemophilus influenzae and Haemophilus parainfluenzae showed slightly decreasing tendency to cefmetazole (CMZ). However, these annual changes were almost negligible. Generally, these microorganisms showed relatively good susceptibilities, every year, to the principal antimicrobialagents being approved for use against Gram-negative bacilli. However, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens and Pseudomonas aeruginosa showed tendencies of decresed susceptibilityto some of the antimicrobial agents. On the other hand, sulfamethoxazole-trimethoprim (ST), CMZ, latamoxef (LMOX), gentamicin (GM) andamikacin (AMK) showed good activities against some of the Gram-negative bacilli towhich no indications areapproved. In conclusion, bedside the identification of the causative microorganisms and the performance of antimicrobialsusceptibility testing, such analyses (graphics of susceptibility tendency ofclinical isolates to variety ofantimicrobial agents) could be used as an index for selection of antimicrobial agents, when emergent and urgent selection of antimicrobial agents is necessary.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.52.333