Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke

Fetuin-A, a protein almost exclusively secreted by the liver, induces insulin resistance and subclinical inflammation in rodents. Circulating fetuin-A levels are elevated in humans with metabolic syndrome and insulin resistance, conditions that are associated with increased risk of cardiovascular di...

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Published in:Circulation (New York, N.Y.) N.Y.), 2008-12, Vol.118 (24), p.2555-2562
Main Authors: WEIKERT, Cornelia, STEFAN, Norbert, SCHULZE, Matthias B, PISCHON, Tobias, BERGER, Klaus, JOOST, Hans-Georg, HÄRING, Hans-Ulrich, BOEING, Heiner, FRITSCHE, Andreas
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - analysis
Biological and medical sciences
Blood and lymphatic vessels
Brain Ischemia
Cardiology. Vascular system
Coronary heart disease
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Follow-Up Studies
Heart
Humans
Medical sciences
Myocardial Infarction - diagnosis
Myocardial Infarction - epidemiology
Myocardial Infarction - etiology
Predictive Value of Tests
Risk
Stroke - diagnosis
Stroke - epidemiology
Stroke - etiology
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Summary:Fetuin-A, a protein almost exclusively secreted by the liver, induces insulin resistance and subclinical inflammation in rodents. Circulating fetuin-A levels are elevated in humans with metabolic syndrome and insulin resistance, conditions that are associated with increased risk of cardiovascular disease. We investigated the association between fetuin-A levels and the risk of future myocardial infarction (MI) and ischemic stroke (IS) in a case-cohort study based on the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study comprising 27 548 middle-aged subjects of the general population. Fetuin-A levels were measured in plasma of 227 individuals who developed MI, in 168 who developed IS, and in 2198 individuals who remained free of cardiovascular events during a mean follow-up of 8.2+/-2.2 years. Individuals in the highest compared with the lowest quintile of plasma fetuin-A had significantly increased risks of MI (relative risk, 3.80; 95% confidence interval, 2.37 to 6.10; P for trend
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.108.814418