Complete Androgen Insensitivity Syndrome—A Review

Abstract This review paper highlights important diagnostic and therapeutic concerns for girls with Complete Androgen Insensitivity Syndrome (CAIS). CAIS is an androgen receptor defect disorder associated with vaginal and uterine agenesis in women with a 46,XY karyotype. The major clinical issues sur...

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Bibliographic Details
Published in:Journal of pediatric & adolescent gynecology 2008-12, Vol.21 (6), p.305-310
Main Authors: Oakes, Meghan B., MD, Eyvazzadeh, Aimee D., MD, Quint, Elisabeth, MD, Smith, Yolanda R., MD, MS
Format: Article
Language:English
Subjects:
Androgen-Insensitivity Syndrome - diagnosis
Androgen-Insensitivity Syndrome - therapy
Female
Genetic disorder
Hormone therapy
Humans
Male
Obstetrics and Gynecology
Pediatrics
Testicular feminization
Vaginal agenesis
Vaginal dilatation
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Summary:Abstract This review paper highlights important diagnostic and therapeutic concerns for girls with Complete Androgen Insensitivity Syndrome (CAIS). CAIS is an androgen receptor defect disorder associated with vaginal and uterine agenesis in women with a 46,XY karyotype. The major clinical issues surrounding this syndrome include timing of gonadectomy, hormone replacement, vaginal dilation, and attention to psychological issues.
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2007.09.006