A Randomized Clinical Trial of Acellular Pertussis Vaccines in Healthy Adults: Dose-Response Comparisons of 5 Vaccines and Implications for Booster Immunization

The safety and immunogenicity of 5 acellular pertussis vaccines (ACVs) were compared in a multicenter, randomized, double-blind trial. A total of 481 healthy adults were given a single intramuscular booster dose of ACV or placebo. Three different dose levels were tested for 4 ACVs: full strength (th...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-08, Vol.180 (2), p.397-403
Main Authors: Keitel, Wendy A., Muenz, Larry R., Decker, Michael D., Englund, Janet A., Mink, ChrisAnna M., Blumberg, Dean A., Edwards, Kathryn M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies
Antibodies, Bacterial - blood
Antigens
Bacteriology
Biological and medical sciences
Bordetella pertussis - immunology
Dosage
Dose response relationship
Dose-Response Relationship, Drug
Dose-Response Relationship, Immunologic
Double-Blind Method
Fundamental and applied biological sciences. Psychology
Humans
Immunization
Immunization, Secondary
Injection sites
Major Articles
Microbiology
Middle Aged
Pertussis Vaccine - adverse effects
Pertussis Vaccine - immunology
Placebos
Symptoms
Toxoids - immunology
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Whooping cough
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Summary:The safety and immunogenicity of 5 acellular pertussis vaccines (ACVs) were compared in a multicenter, randomized, double-blind trial. A total of 481 healthy adults were given a single intramuscular booster dose of ACV or placebo. Three different dose levels were tested for 4 ACVs: full strength (the dose level proposed for infant immunization), one-third strength, and one-tenth strength. For 1 multicomponent vaccine, only the pertussis toxoid dose level varied. Minor injection site reactions were common and similar in frequency among vaccinated groups. Late-onset injection site reactions were seen in all ACV groups. Dose-related increases in mean antibody titers against vaccine antigens were seen after immunization with all ACVs. Antibody responses against antigens not known to be present in the vaccines were detected after immunization with 4/5 ACVs. Antibody levels fell significantly during the year after immunization. These data support evaluation of ACVs for broader use among adolescents and adults.
ISSN:0022-1899
1537-6613
DOI:10.1086/314869