Rat visceral yolk sac (VYS) and placenta mitochondrial features during the placentation period

The transference of the nutritional function from the VYS to the chorioallantoic placenta during middle pregnancy is a key event for the activation of embryo oxidative metabolism. However, the metabolic adaptations occurring in these tissues during this critical period have not been studied to date....

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Bibliographic Details
Published in:Mitochondrion 2008-12, Vol.8 (5-6), p.389-395
Main Authors: Alcolea, M P, Colom, B, Amengual-Cladera, E, Lladó, I, Gianotti, M, García-Palmer, F J
Format: Article
Language:English
Subjects:
Animals
Cyclooxygenase 1 - analysis
DNA, Mitochondrial - analysis
Female
Mitochondria - physiology
Mitochondrial Proteins - analysis
Organ Size
Oxidative Phosphorylation
Placenta - ultrastructure
Placentation
Pregnancy
Rats
Rats, Wistar
Yolk Sac - ultrastructure
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Summary:The transference of the nutritional function from the VYS to the chorioallantoic placenta during middle pregnancy is a key event for the activation of embryo oxidative metabolism. However, the metabolic adaptations occurring in these tissues during this critical period have not been studied to date. Herein, we investigate the VYS and placenta mitochondrial adaptations throughout gestational days 11, 12 and 13. The results reflect that, during the placentation period, mitochondrial proliferation predominates over differentiation in placenta. Besides, VYS development and mitochondriogenesis show a slowdown despite maintaining the mitochondrial OXPHOS capacities, hence becoming a supporting tissue until the placenta functions are completely available.
ISSN:1567-7249
DOI:10.1016/j.mito.2008.09.001