Placental transfer of IgG antibodies against Haemophilus influenzae type b capsular polysaccharide in Brazilian term and preterm newborns

Placental transfer of antibodies to polysaccharide antigens is still a controversial subject. The incidence of invasive Haemophilus influenzae type b (Hib) infections is high in countries where the vaccine has not been included in routine immunization schedules. In the present work, we proposed to e...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1999-06, Vol.45 (3), p.171-173
Main Authors: NAGAO, A. T, COSTA-CARVALHO, B. T, ARSLANIAN, C, SOLE, D, NASPITZ, C, CARNEIRO-SAMPAIO, M. M. S
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - immunology
Bacterial Capsules - immunology
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Brazil
Female
Fetal Blood - immunology
Haemophilus influenzae type b - immunology
Human bacterial diseases
Humans
Immunoglobulin G - immunology
Infant, Newborn - blood
Infant, Premature - blood
Infectious diseases
Maternal-Fetal Exchange - immunology
Medical sciences
Pregnancy - blood
Tropical medicine
Urban Health
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Summary:Placental transfer of antibodies to polysaccharide antigens is still a controversial subject. The incidence of invasive Haemophilus influenzae type b (Hib) infections is high in countries where the vaccine has not been included in routine immunization schedules. In the present work, we proposed to evaluate the natural immune response to Hib capsular polysaccharide in term and preterm Brazilian newborns and their respective mothers. Although the means, medians, and ranges of antibody titres in paired maternal and cord sera from preterm neonates were similar, the maternal levels were slightly higher than the cord levels and a poor correlation between these levels was verified. Term neonates showed similar antibody levels to those of their respective mothers and a very significant correlation between these levels was observed.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/45.3.171