Consistent Associations of HLA Class I and II and Transporter Gene Products with Progression of Human Immunodeficiency Virus Type 1 Infection in Homosexual Men

Polymorphic products of genes in the HLA region contributing to variability in the course of human immunodeficiency virus type 1 (HIV-1) infection were identified by screening 375 Caucasian seroconverters who were aggregated from 3 cohorts. AIDS-free time was related to numerous (15) class I alleles...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-08, Vol.180 (2), p.299-309
Main Authors: Keet, Ireneus P. M., Tang, James, Klein, Michèl R., LeBlanc, Susan, Enger, Cheryl, Rivers, Charles, Apple, Raymond J., Mann, Dean, Goedert, James J., Miedema, Frank, Kaslow, Richard A.
Format: Article
Language:English
Subjects:
Adult
AIDS
AIDS/HIV
Algorithms
Alleles
Antigen Presentation
Biological and medical sciences
Carrier Proteins - genetics
Carrier Proteins - metabolism
CD4 Lymphocyte Count
Cohort Studies
Disease Progression
Fundamental and applied biological sciences. Psychology
Genes, MHC Class I
Genes, MHC Class II
Genetics
Haplotypes
histocompatibility antigen HLA
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class I - metabolism
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - metabolism
HIV 1
HIV Infections - immunology
HIV Infections - physiopathology
HIV Seropositivity
HLA antigens
Homosexuality, Male
Homozygote
Human immunodeficiency virus 1
Human viral diseases
Humans
Infections
Infectious diseases
Major Articles
Male
Medical genetics
Medical sciences
Microbiology
T lymphocytes
Transporter protein
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
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Summary:Polymorphic products of genes in the HLA region contributing to variability in the course of human immunodeficiency virus type 1 (HIV-1) infection were identified by screening 375 Caucasian seroconverters who were aggregated from 3 cohorts. AIDS-free time was related to numerous (15) class I alleles, alone or in conjunction with transporter protein variants, to homozygosity at the A or B locus, and to alleles of two class II haplotypes. A prognostic scoring algorithm derived from the 3 cohorts captured multiple HLA contributions to protection or to risk (relative hazard = 0.57–60 per unit increase in score, all P ≪.001). The impact of HLA was strong and appeared independent of the effects of chemokine receptor/ligand polymorphisms and antiretroviral treatment. The algorithm also predicted divergent rates of CD4+ cell decline in 2 other groups, totaling 227 seropositive persons (P = .06 —
ISSN:0022-1899
1537-6613
DOI:10.1086/314862