Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts

Recent advances in microbial steroid hydroxylation are covered, including new biocatalysts and substrate groups and new methodologies such as the use of low-water systems, immobilised biocatalysts, genetically constructed biocatalysts and enzyme mimics. Mechanistic factors that control the regiochem...

Full description

Saved in:
Bibliographic Details
Published in:Steroids 1999-03, Vol.64 (3), p.178-186
Main Author: Holland, Herbert L
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Catalysis
Enzyme
Fundamental and applied biological sciences. Psychology
Hydroxylation
Methods. Procedures. Technologies
Microorganism
Steroid
Steroid Hydroxylases - metabolism
Steroids - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent advances in microbial steroid hydroxylation are covered, including new biocatalysts and substrate groups and new methodologies such as the use of low-water systems, immobilised biocatalysts, genetically constructed biocatalysts and enzyme mimics. Mechanistic factors that control the regiochemistry and stereochemistry of steroid hydroxylation are also discussed.
ISSN:0039-128X
1878-5867
DOI:10.1016/S0039-128X(98)00085-3