Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency

Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether GH replacement remains beneficial over the long term. We assessed the effects of long term GH replacement on body composition, bone mineral density, and cardiac function. T...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 1999-07, Vol.84 (7), p.2373-2380
Main Authors: TER MAATEN, J. C, DE BOER, H, KAMP, O, STUURMAN, L, VAN DER VEEN, E. A
Format: Article
Language:English
Subjects:
Adult
Anthropometry
Biological and medical sciences
Blood Pressure
Body Composition - drug effects
Bone Density - drug effects
Echocardiography
Heart - drug effects
Heart - physiology
Heart Rate
Hormones. Endocrine system
Human Growth Hormone - administration & dosage
Human Growth Hormone - adverse effects
Human Growth Hormone - deficiency
Humans
Insulin-Like Growth Factor I - metabolism
Male
Medical sciences
Pharmacology. Drug treatments
Skinfold Thickness
Thyroxine - blood
Triiodothyronine - blood
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Summary:Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether GH replacement remains beneficial over the long term. We assessed the effects of long term GH replacement on body composition, bone mineral density, and cardiac function. Thirty-eight men with childhood-onset GH deficiency were studied for a period of 3-5 yr. Measurements included anthropometry, computed tomographic scanning of abdomen and upper leg, bone densitometry, echo cardiography, and bicycle ergometry. The initial GH dose of 1-3 IU/m2 x day (9-27 microg/kg) was gradually tapered to 1.30+/-0.38 IU/m2 x day (11 g/kg), aiming at physiological insulin-like growth factor I levels. During the study, leg muscle mass progressively increased by 28.7% (P
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.84.7.2373