Agalactosyl IgG is elevated in patients with active spondyloarthropathy

Patients with rheumatoid arthritis or with Crohn's disease have deficient galactosylation of serum IgG [Gal(0)]. To study whether such deviation occurs in patients with spondyloarthropathy (SPA), we studied the percentage incidence of Gal(0) corrected for age [Gal(0)corr] in 47 SPA patients und...

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Bibliographic Details
Published in:Rheumatology international 1999, Vol.18 (5-6), p.171-176
Main Authors: LEIRISALO-REPO, M, HERNANDEZ-MUNOZ, H. E, ROOK, G. A. W
Format: Article
Language:English
Subjects:
Adult
Arthritis, Reactive - immunology
Biological and medical sciences
Biomarkers - blood
Diseases of the osteoarticular system
Female
Humans
Immunoglobulin G - blood
Inflammatory joint diseases
Male
Medical research
Medical sciences
Middle Aged
Prognosis
Reference Values
Sensitivity and Specificity
Severity of Illness Index
Spondylitis, Ankylosing - immunology
Statistics, Nonparametric
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Summary:Patients with rheumatoid arthritis or with Crohn's disease have deficient galactosylation of serum IgG [Gal(0)]. To study whether such deviation occurs in patients with spondyloarthropathy (SPA), we studied the percentage incidence of Gal(0) corrected for age [Gal(0)corr] in 47 SPA patients undergoing ileocolonoscopy and correlated the findings with clinical variables and prognosis of the patients. Gal(0)corr was elevated in 36% of the patients. Such patients had a higher number of inflamed joints (P < 0.02), higher ESR (P < 0.001) and CRP (P < 0.001). Elevated Gal(0)corr was also of prognostic significance: at 6-month follow-up those with elevated levels had a higher number of inflamed joints (P < 0.02) and ESR (P < 0.05). The presence of high Gal(0)corr did not associate with gut inflammation. In conclusion, a proportion of SPA patients has elevated levels of Gal(0), the amount of which correlates with severity of the disease and is a prognostic marker for chronicity of the disease.
ISSN:0172-8172
1437-160X
DOI:10.1007/s002960050080