CD14

The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 1999-05, Vol.31 (5), p.545-549
Main Author: Schütt, Christine
Format: Article
Language:English
Subjects:
Animals
Endotoxin receptor
Humans
Innate immunity
Lipopolysaccharide Receptors - chemistry
Lipopolysaccharide Receptors - physiology
Lipopolysaccharide Receptors - therapeutic use
Lipopolysaccharides - metabolism
Macrophages - metabolism
Mice
Mice, Knockout
Models, Biological
Receptors, Immunologic - physiology
Sepsis
Sepsis - therapy
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Summary:The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not have a membrane spanning domain it cannot transmit a signal into the cell. Some as yet unidentified accessory protein is thought to be involved. It will be important to clarify the signalling systems involved since they may provide a therapeutic target for sepsis intervention strategies.
ISSN:1357-2725
1878-5875
DOI:10.1016/S1357-2725(98)00153-8