Olanzapine in the treatment of adolescent acute mania: a report of seven cases

Background: Clozapine may be effective in adults and adolescents with treatment-resistant bipolar disorder. Olanzapine has a receptor affinity profile similar to that of clozapine. Methods: The responses of seven consecutive adolescents (ages 12–17) with DSM-IV bipolar disorder, manic episode, treat...

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Bibliographic Details
Published in:Journal of affective disorders 1999-06, Vol.53 (3), p.279-283
Main Authors: Soutullo, Cesar A, Sorter, Michael T, Foster, Keith D, McElroy, Susan L, Keck, Paul E
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Antipsychotic
Atypical
Benzodiazepines
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - diagnosis
Bipolar Disorder - drug therapy
Child
Female
Humans
Male
Mania
Medical sciences
Neuropharmacology
Olanzapine
Pharmacology. Drug treatments
Pirenzepine - analogs & derivatives
Pirenzepine - therapeutic use
Psycholeptics: tranquillizer, neuroleptic
Psychology, Adolescent
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Serotonin Uptake Inhibitors - therapeutic use
Treatment Outcome
Treatment-resistant
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Summary:Background: Clozapine may be effective in adults and adolescents with treatment-resistant bipolar disorder. Olanzapine has a receptor affinity profile similar to that of clozapine. Methods: The responses of seven consecutive adolescents (ages 12–17) with DSM-IV bipolar disorder, manic episode, treated with olanzapine were evaluated. Response to olanzapine was rated as marked, moderate, minimal, none or worse. Results: Five (71%) adolescents showed a marked or moderate response. The mean±SD olanzapine dose was 0.146±0.086 mg/kg/day (11±6 mg/day). Conclusion: Olanzapine may have antimanic effects in some adolescents with acute mania. Controlled studies of olanzapine in adolescent bipolar disorder appear to be warranted.
ISSN:0165-0327
1573-2517
DOI:10.1016/S0165-0327(98)00119-0